Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression

查看全文 作　　者：Marko [1]Duvnjak;Neven Bari[1];Vedran Tomai[1];Ivan Leroti[1]

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Medicine,'Sestre milosrdnice' University Hospital

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第48期,共5页

摘　　要：The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and cirrhosis.Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease presentation.Most of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis.Although there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. 关键词：基因多态性发病机制脂肪肝酒精性疾病单核苷酸多态性肝纤维化遗传变化

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Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression

参考文献(45)

引证文献(6)

耦合文献(95)

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