Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

查看全文 作　　者：Chengyang [1]Huang;Yang [2]Xiang;Yanru [2]Wang;Xia [2]Li;Longyong [2]Xu;Ziqi [2]Zhu;Ting [1]Zhang;Qingqing [1]Zhu;Kejing [1]Zhang;Naihe [1]Jing;Charlie Degui [2]Chen

机构地区：[1]Laboratory of Molecular Cell Biology;[2]State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China

出　　处：《Cell Research》索引2010年第20卷第2期,共12页

基　　金：Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Anning Lin (The University of Chicago) for the critical reading of the paper, members in the Chen lab for technical help, the cell biology and molecular biology core facilities for confocal study and Q-PCR, and Shanghai Biochip Co Ltd. for microarray analysis. The H3K27me2 antibody was kindly provided by Li Tang (Fudan University) and Thomas Jenuwein (Research Institute of Molecular Pathology, The Vienna Biocenter). This work was supported by the National Basic Research Program of China (2007CB957900, 2006CB943902, 2007CB947101, 2008KR0695, 2009CB941100, 2005CB522704), the Chinese Academy of Sciences (KSCX2-YW-R-04), the National Natural Science Foundation of China (90919026, 30870538,30623003, 30721065, 30830034, 90919046), the Shanghai Pujiang Program (0757S11361), the Shanghai Key Project of Basic Science Research (06DJ14001, 06DZ22032, 08DJ1400501), and the Council of Shanghai Municipal Government for Science and Technology (088014199). 摘　　要：histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 关键词：组蛋白H3 神经分化异性脱甲基小鼠胚胎干细胞转录抑制早期阶段催化活性

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Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

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