Nanomechanics of individual amyloid fibrils using atomic force microscopy

查看全文 作　　者：ZHOU XingFei CUI ChengYi ZHANG JinHai LIU JianHua LIU [1]JingSong

机构地区：[1]Nanomaterials Laboratory, College of Sciences, Ningbo University, Ningbo 315211, China

出　　处：《Chinese Science Bulletin》索引2010年第55卷第16期,共5页

基　　金：supported by the National Natural Science Foundation of China (10604034);Natural Science Foundation of Zhejiang Province (Y606309);K. C. Wong Magna Fund in Ningbo University 摘　　要：Compression elasticity of glucagon amyloid fibrils in the transverse direction was investigated by a nanoindentation approach based on atomic force microscopy (AFM).With force-volume mapping, we obtained the correlations between radially applied force and compression of amyloid fibrils, from which the radial compressive elasticity can be deduced.The estimated elastic modulus at three typical locations of fibrils varied from (0.72±0.80) GPa to (1.26±0.62) GPa under small external forces, imply-ing the structural heterogeneity of different fibrils. 关键词：原子力显微镜淀粉纤维纳米力学粉样压缩弹性径向压缩政府采购纳米压痕法

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Nanomechanics of individual amyloid fibrils using atomic force microscopy

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