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Molecular characterization of avian influenza virus (H7N8) isolated from poultry in Central China in the mid-1980s

查看全文 作　　者：YANG JiaLin XIA Han ZHAO JiuRu HE XiaoBin PAN LiMin TANG Shuang ZHANG Zhong KOU Zheng LI [1]TianXian 高影响力作者 机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China高影响力机构 出　　处：《Chinese Science Bulletin》索引2010年第55卷第16期,共6页高影响力期刊 基　　金：supported by the National Basic Research Program of China (2010CB534005);he State Basic Project of Science and Technology of China (2007FY2010700 and 2009ZX10004-109);the National Natural Science Foundation of China (30970024 and 30900060);the Knowl-edge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW- N-065, KSCX-YW-R-157, KSCX2-YW-R-158, KSCX-YW-R159, INFO-115- C01-SDB3-01, INFO-115-C01_SDB4-21, IN-FO-115-D02 and IN-FO-115-C01-SDB2-02) 摘　　要：The molecular and pathogenic properties of avian influenza virus (A/duck/Hubei/216/1985/H7N8) isolated from Hubei Province of China in 1985 were characterized.The hemagglutinin gene (HA) of Dk/Hb/216/85/H7N8 had the multiple amino acid se-quences (-PEIPKGRG-) at the connecting peptide between HA1 and HA2, which is considered to be a distinguishing molecular characteristic of low pathogenicity.The key sites of host markers among the genes (M, NP, NS, PA and PB2) of Dk/Hb/ 216/85/H7N8 were similar to those of H5N1 viruses.Phylogenetic analysis showed that the genes (M, NS and PB2) of Dk/Hb/ 216/85/H7N8 clustered closely with those of Gs/Guangdong/1996/H5N1 (Gs/GD/96), implying that three ancient genes of Gs/ GD/96-like viruses had been circulating in Central China during the 1980s.In experimental infection, Dk/Hb/216/85/H7N8 was lowly pathogenic to chickens and mice, consistent with the molecular feature of HA gene. 关 键 词：禽流感病毒 分子特性 中国 年代 血凝素基因 孤立 中期 家禽
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