TGF-β signaling in aortic aneurysm: another round of controversy

查看全文 作　　者：Fuyu Lin Xiao [1]Yang

机构地区：[1]State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing 100071, China

出　　处：《Journal of Genetics and Genomics》索引2010年第37卷第9期,共9页

基　　金：supported by the grants from State Key Laboratory of Proteomics (No. SKLP-K200902);Chinese Key Program for Drug Invention (No. 2009ZX09501-027);Chinese National Key Program on Basic Research (Nos. 2005CB522506, 2006CB943501 and 2006BAI23B01-3) 摘　　要：Aortic aneurysm (AA) is a common health problem with high mortality and no effective drugs. Transforming growth factor-β (TGF-β) superfamily members regulate various cellular processes, and TGF-β signaling has key roles in development, tissue homeostasis, and diseases. Interest in the role of TGF-β signaling in the pathogenesis of AAs has recently emerged, particularly since genetic studies demonstrated an association between gene mutations in components of TGF-β signaling and AAs. However, paradoxical discoveries have implicated dysregulated TGF-β signaling in aneurysm formation, complicating the precise functional role for TGF-β in aneurysm development and progression. Furthermore, interventions targeting towards TGF-β signaling using losartan, which may represent a suitable therapeutic option for AAs, were subject to skepticism especially because of conflicting experimental results obtained from TGF-β antibody treatment without knowledge of the underlying mechanism. We propose a TGF-β aneurysm paradox, which would provide a good opportunity for the development of genetic mouse models of AA. These models would be used to clarify the mechanisms underlying TGF-β signaling, which would translate into novel pharmacologic therapies based on the new molecular discoveries. 关键词：转化生长因子动脉瘤信号发病机制基因突变小鼠模型氨基酸健康问题

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TGF-β signaling in aortic aneurysm: another round of controversy

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