Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR a and ~ expression and reducing TC, MMP-9, and Cat S levels

查看全文 作　　者：Yan-wen [1]QIN;Ping [2]YE;Ji-qiang [1]HE;Li [2]SHENG;Lu-ya [1]WANG;Jie [1]DU

机构地区：[1]Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China;[2]Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China

出　　处：《Acta Pharmacologica Sinica》索引2010年第31卷第10期,共9页

基　　金：Acknowledegments This work was supported by grants from the National Natural Science Foundation of China (No 30872713) and the Beijing Natural Science Foundation of China (No 7082020, 7082083). 关键词：过氧化物酶体增殖物激活受体载脂蛋白E 心肌肥厚辛伐他汀肝纤维化基因缺陷 MMP 降低胆固醇

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Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR a and ~ expression and reducing TC, MMP-9, and Cat S levels

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