Remodeling of skin nerve fibers during burn wound healing

查看全文 作　　者：Yongqiang [1]Feng;Xia [2]Li;Rui [3]Zhang;Yu [4]Liu;Tingting [1]Leng;Yibing [1]Wang

机构地区：[1]Department of Bum and Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China;[2]Department of Bum, Weihai Municipal Hospital, Weihai 264200, Shandong Province, China;[3]Department of Pathology, Shandong Medical College, Jinan 250002, Shandong Province, China;[4]Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China

出　　处：《Neural Regeneration Research》索引2010年第5卷第19期,共6页

基　　金：the Natural Science Foundation of Shandong Province, No.Y2002C29 摘　　要：Burn wound healing involves a complex sequence of processes.Recent studies have revealed that skin reinnervation may have an impact on physiological wound repair.Few studies have addressed the process of reinnervation and morphological changes in regenerated nerve fibers.The regeneration of neurites during full-thickness burn wound healing was determined by immunofluorescent staining using an anti-neurofilament protein monoclonal antibody,and three-dimensional morphology was observed under a laser scanning confocal microscope.Morphology and the volume fraction of collagen and nerve fibers were measured.Skin reinnervation increased during wound healing,peaked during the proliferative scar stage,and then decreased to lower levels during the maturation period.The results from the skin nerve fibers correlated with those from collagen using semi-quantitative analysis.Disintegration and fragmentation were observed frequently in samples from the proliferative stage,and seldom occurred during the maturation stage.There was a remodeling process of regenerated nerve fibers during wound healing,which comprised changed innervation density and topical morphology.The mechanism of remodeling for nerve fibers requires further investigation. 关键词：神经纤维愈合过程创面修复皮肤烧伤形态学变化神经再生免疫荧光染色

相关文献

参考文献（19）
引证文献（4）
耦合文献（17）

参考文献(19)

引证文献(4)

耦合文献(17)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Remodeling of skin nerve fibers during burn wound healing

参考文献(19)

引证文献(4)

耦合文献(17)

用户提示