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Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China

查看全文 作　　者：ZHU [1]JingYuan;DUAN [2,3]GuangCai;YANG [2]HaiYan;FAN [4]QingTang;XI [2]YuanLin 高影响力作者 机构地区：[1]Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan China;[2]Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan China;[3]Henan University of Science & Technology, Luoyang 471003, Henan, China;[4]The Key Laboratory of Molecular Medicine in Henan Province, Zhengzhou 450052, Henan, China高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2011年第24卷第1期,共6页高影响力期刊 基　　金：supported by the Research Fund from Ministry of Health of the People’s Republic of China, WKJ2007‐2‐024 摘　　要：Objective To investigate the characteristic of integrons and the relationship between integrons and antimicrobial resistance in Shigella spp. Methods Ninety Shigella strains (83 S. flexneri and 7 S. sonnei) were isolated from the stools of patients in China. Susceptibility to 8 antimicrobials was tested for all isolated strains. PCR, RFLP and sequencing analysis of integrons were applied to all of them. Results High prevalence of multi‐drug resistance (95.6%) was identified. Of the isolates 79 (87.8%) carried integrase genes of class 1 integron (3.3%), class 2 integron (10.0%) or both (74.4%). No intI3 was detected in the tested isolates. The prevalence of intI2 was significantly higher in isolates with multi‐drug resistance to at least 3 antibiotics than that in isolates with resistance to 2 and less antibiotics (P<0.05). Gene cassettes dfrA17‐aadA5, dfrA12‐orfF‐aadA2 of class 1 integron and dfrA1‐sat1‐aadA1 of class 2 integron were identified. Conclusion The class 2 integron may play a role in the emergence of multi‐drug resistance in Shigella spp. 关 键 词：痢疾杆菌 整合子 耐药性 中国 抗生素敏感性 特征 PCR扩增 测序分析
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