Quantification of HBsAg:Basic virology for clinical practice

查看全文 作　　者：Jung Min [1]Lee;Sang Hoon [2,3]Ahn

机构地区：[1]Department of Internal Medicine,Yonsei University College of Medicine;[2]Department of Internal Medicine,Institute of Gastroenterology,Yonsei University College of Medicine;[3]Liver Cirrhosis Clinical Research Center

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第3期,共7页

基　　金：Supported by The Grant of the Bilateral International Collaborative R&D Program from the Ministry of Knowledge Economy;the Good Health R&D Project from the Ministry for Health,Welfare and Family Affairs,South Korea (A050021) 摘　　要：Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has long served as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, which have allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and apply its utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantification of HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics. 关键词：乙肝表面抗原临床实践病毒学乙型肝炎表面抗原 HBSAG 基因突变生物学特性病毒感染

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Quantification of HBsAg:Basic virology for clinical practice

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