Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors

查看全文 作　　者：Patricia [1]Kuiper;Lukas JAC [2]Hawinkels;Eveline SM de Jonge-[1]Muller;Izk [1]Biemond;Cornelis BHW [1]Lamers;Hein W [1]Verspaget

机构地区：[1]Department of Gastroenterology and Hepatology,Leiden University Medical Centre;[2]Department of Molecular Cell Biology and Centre for Biomedical Genetics,Leiden University Medical Centre

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第2期,共7页

基　　金：Supported by Centre for Biomedical Genetics and Dutch Cancer Society RUL2005-3371(Hawinkels LJAC) 摘　　要：AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. 关键词：血管内皮生长因子肿瘤组织神经内分泌血管生成标记免疫组织化学 NETS ELISA法

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Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors

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