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Differentiation of Crohn’s disease from intestinal tuberculosis in India in 2010

查看全文 作  者:Anna Benjamin [1]Pulimood;Deepak Narayan [2]Amarapurkar;Ujjala [3]Ghoshal;Mathew [4]Phillip;Cannanore Ganesh [5]Pai;Duvvur Nageshwar [6]Reddy;Birender [7]Nagi;Balakrishna Siddhartha [1]Ramakrishna 高影响力作者 机构地区:[1]Department of Gastrointestinal Sciences, Christian Medical College;[2]Department of Gastroenterology, Bombay Hospital and Medical Research Centre;[3]Department of Microbiology, Sanjay Gandhi Postgraduate Institute;[4]PVS Institute of Digestive Diseases, PVS Hospital;[5]Department of Gastroenterology and Hepatology, Kasturba Medical College;[6]Asian Institute of Gastroenterology, Hyderabad, Andhra Pradesh 500082, India;[7]Department of Gastroenterology, Postgraduate Institute高影响力机构 出  处:《World Journal of Gastroenterology》索引2011年第17卷第4期,共11页高影响力期刊 摘  要:Differentiating intestinal tuberculosis from Crohn’s disease (CD) is an important clinical challenge of considerable therapeutic significance. The problem is of greatest magnitude in countries where tuberculosis continues to be highly prevalent, and where the incidence of CD is increasing. The final clinical diagnosis is based on a combination of the clinical history with endoscopic studies, culture and polymerase chain reaction for Mycobacterium tuberculosis, biopsy pathology, radiological investigations and response to therapy. In a subset of patients, surgery is required and intraoperative findings with pathological study of the resected bowel provide a definitive diagnosis. Awareness of the parameters useful in distinguishing these two disorders in each of the different diagnostic modalities is crucial to accurate decision making. Newer techniques, such as capsule endoscopy, small bowel enteroscopy and immunological assays for Mycobacterium tuberculosis, have a role to play in the differentiation of intestinal tuberculosis and CD. This review presents currently available evidence regarding the usefulness and limitations of all these different modalities available for the evaluation of these two disorders. 关 键 词:结核病 小肠 分化 临床诊断 印度 结核分枝杆菌 反应结合 放射性调查
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