Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

查看全文 作　　者：Patrícia Koehler-[1,2,3]Santos;Patricia [1,4]Izetti;Jamile [1,5]Abud;Carlos Eduardo [1,2]Pitroski;Silvia Liliana [1,3]Cossio;Suzi Alves [6,7,8]Camey;Cláudio [9,10]Tarta;Daniel C [9,10]Damin;Paulo Carvalho [9,10]Contu;Mario Antonello [9,10]Rosito;Patricia Ashton-[1,2,3,11,12]Prolla;Joāo Carlos [5,13]Prolla

机构地区：[1]Genomic Medicine Laboratory,Experimental Research Center,Hospital de Clínicas de Porto Alegre;[2]Post-Graduate Program in Medical Sciences,Federal University of Rio Grande do Sul;[3]National Institute for Populational Medical Genetics;[4]Medical School,Federal University of Rio Grande do Sul;[5]Post-Graduate Program in Gastroenterological Sciences,Federal University of Rio Grande do Sul;[6]Department of Statistics,Federal University of Rio Grande do Sul;[7]Post-Graduate Program in Epidemiology,Federal University of Rio Grande do Sul;[8]Research and Post-Graduation Group,Hospital de Clínicas de Porto Alegre;[9]Division of Coloproctology,Hospital de Clínicas de Porto Alegre;[10]Department of Surgery,Federal University of Rio Grande do Sul;[11]Medical Genetics Service,Hospital de Clínicas de Porto Alegre;[12]Department of Genetics,Federal University of Rio Grande do Sul;[13]Service of Pathology,Hospital de Clínicas de Porto Alegre,Porto Alegre-RS,90035-903,Brazil

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第6期,共8页

摘　　要：AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. 关键词：风险评估大肠癌综合征患者微卫星不稳定性诊疗手术基础

相关文献

参考文献（46）
引证文献（2）
耦合文献（0）

参考文献(46)

引证文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

参考文献(46)

引证文献(2)

用户提示