Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

查看全文 作　　者：Yi [1,2]Guo;Jing [3]Fang;Yan [4]Liu;Hai-Hui [3]Sheng;Xiao-Yan [3]Zhang;Hai-Na [1,2]Chai;Wei [4]jin;Ke-Hao [3]Zhang;Chang-Qing [1]Yang;Heng-jun [1,2]Gao

机构地区：[1]DepartmeTo ntngji UniversO ity,f GastroenteroloSh gy,anghai 200065Tongjc ihinaHospital Affiliated to;[2]National EngineeringCenter for Biochip at Shanghai, Shanghai 201203, China;[3]National Engineering Center for Biochip at Shanghai, Shanghai201203, China;[4]Department of Cardiology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai200025, China

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第13期,共7页

基　　金：Supported by Shanghai 'Phosphor' Science Foundation, China, No. 09QB1403100;the National High Technology Researchand Development Program of China, No. 2006AA020704 and 2006AA02A407;the Funds for Key Programs of Ministry ofHealth of China, No.2008ZX10002-017 摘　　要：AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed. 关键词：单核苷酸多态性胃癌风险中国人群 LOGISTIC回归模型限制性片段长度多态性基因型频率协会

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Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

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