Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass

查看全文 作　　者：Ying-Jie Sun Hui-Juan Cao Qiang Jin Yu-Gang Diao Tie-Zheng [1]Zhang

机构地区：[1]Department of Anesthesiology, General Hospital ofShenyang Commend, Shenyang 110840, Liaoning Province, China

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第16期,共6页

基　　金：Supported by A grant from the Doctor Priming Foundation of Liaoning Province,No. 20091099 摘　　要：AIM:To test the ability of penehyclidine hydrochloride (PHC) to attenuate intestinal injury in a rat cardiopulmonary bypass (CPB) model.METHODS:Male Sprague-Dawley rats were randomly divided into six groups (eight each):sham-operated control;sham-operated low-dose PHC control (0.6 mg/kg);sham-operated high-dose PHC control (2.0 mg/kg);CPB vehicle control;CPB low-dose PHC (0.6 mg/kg);and CPB high-dose PHC (2.0 mg/kg).Blood samples were collected from the femoral artery 2 h after CPB for determination of plasma diamine oxidase (DAO),D-lactate and endotoxin levels.Spleen,liver,mesenteric lymph nodes and lung were removed for biochemical analyses.Intestinal tissue ultrastructure was examined by electron microscopy.RESULTS:In the sham-operated groups,high-and low-dose-PHC had no significant impact on the levels of DAO,D-lactate and endotoxin,or the incidence of intestinal bacterial translocation (BT).Serum levels of DAO,D-lactate,endotoxin and the incidence of intestinal BT were significantly increased in the surgical groups,compared with the sham-operated groups (0.543 ± 0.061,5.697 ± 0.272,14.75 ± 2.46,and 0/40 vs 1.038 ± 0.252,9.377 ± 0.769,60.37 ± 5.63,and 30/40,respectively,all P < 0.05).PHC alleviated the biochemical and histopathological changes in a dosedependent manner.Serum levels of DAO,D-lactate,and endotoxin and the incidence of intestinal BT in the high-dose PHC group were significantly lower than in the low-dose PHC group (0.637 ± 0.064,6.972 ± 0.349,29.64 ± 5.49,and 14/40 vs 0.998 ± 0.062,7.835 ± 0.330,38.56 ± 4.28,and 6/40,respectively,all P < 0.05).CONCLUSION:PHC protects the structure and function of the intestinal mucosa from injury after CPB in rats. 关键词：肠道损伤体外循环大鼠屏障功能电子显微镜观察卫生保健原发性肝癌肠系膜淋巴结

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Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass

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