Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China

查看全文 作　　者：Xiaolan [1]Zhang;Gaofeng [1]Liang;Xiangying [2]Zeng;Jing [1]Zhou;Guoying [1,2]Sheng;Jiamo [1,2]Fu

机构地区：[1]Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China;[2]State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China

出　　处：《Journal of Environmental Sciences》索引2011年第23卷第6期,共8页

基　　金：supported by the National Basic Research Program(973) of China(No.2008CB418200);the National Natural Science Foundation of China(No. 40872204);the Key Subject of Shanghai Municipality (No.S30109) 摘　　要：Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. 关键词：合成麝香中国东部长江三角洲人乳城市香水三硝基苯二甲苯麝香

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Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China

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