Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis

查看全文 作　　者：Yanqing [1]Wu;Ying [1]Gao;Lingqun [2]Zhu;Yonghong [2]Gao;Dongmei [2]Zhang;Lixia [2]Lou;Yanfang [2]Yan

机构地区：[1]Department of Neurology, Chinese Medicine Key Research Room of Encephalopathy Syndrome and Treatment of the State Administration of TCM People's Republic of China, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;[2]Key Laboratory of Chinese Internal Medicine, Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第15期,共7页

基　　金：the National Natural Science Foundation of China, No. 30672692 摘　　要：This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantitative PCR to measure the levels of mRNAs specific to the T cell markers CD4 and CD8,and the monocyte marker CD11b.In addition,we used Evans blue dye extravasation in the spinal cord and brain tissues to assess blood-brain barrier permeability.The results indicated that an increase in blood-brain barrier permeability was associated with an increase in CD4,CD8 and CD11b mRNA expression in experimental autoimmune encephalomyelitis mice.Yishendaluo decoction administration significantly reversed inflammatory cell accumulation in cerebral tissues of experimental autoimmune encephalomyelitis mice. 关键词：自身免疫性脑脊髓炎血脑屏障实验性小鼠整性实时荧光定量PCR mRNA表达

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Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis

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