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The Influence of Phacoemulsification on Corneal Endothelia Cells at Varying Blood Glucose Levels

查看全文 作　　者：RuiMing Yang Xiangyin Sha Mingbing Zeng Yingqian Tan Yu Zheng Feihong [1]Fan 高影响力作者 机构地区：[1]Department of Ophthalmology, the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260, China高影响力机构 出　　处：《Eye Science》索引2011年第26卷第2期,共5页高影响力期刊 摘　　要：Purpose:To investigate the influence of phacoemulsification on corneal endothelial cells in diabetes patients and normal controls. Methods:Phacoemulsification and intraocular lens implantation were performed on 75 patients with diabetic cataract (126 eyes) who were divided into two groups: Trial group 1 (Glu≤6 mmol/L); Trial group 2 (Glu 6-10 mmol/L) and 65 nondiabetic controls (112 eyes).The density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia were measured before surgery and 1 day,1 month and 3 months postoperatively. Results: There was no statistical difference in the density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia prior to phacoemulsification.(P>0.05) between the three groups.The density and percentage of hexagonal cells of the corneal endothelia decreased significantly after surgery in all three groups(P<0.05),while the Coefficient of variation increased in all groups(P<0.05). The rate of loss of corneal endothelial cells in the diabetic groups was significantly higher than for the control group (P<0.05), the percentage of hexagonal cells in the diabetic groups was significantly lower than for the control group (P<0.05), and the coefficient of variation in the diabetic groups was significantly higher than for the control group (P<0.05) at 1 day, 1 month and 3 months post-operatively. There was no statistical difference between the two diabetic groups in terms of these post-operative measurements. Conclusion:The corneal endothelium of diabetic patients is more prone to damage from phacoemulsification. It is advisable to evaluate the corneal endothelium routinely prior to phacoemulsification, particularly in diabetic persons. 关 键 词：角膜内皮细胞 超声乳化 白内障 血糖水平 糖尿病人 变异系数 对照组 六角形
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