Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats

查看全文 作　　者：Deshan Liu Weiwei Lin Wei Gao Ping Chang Wei [1]Li

机构地区：[1]Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第21期,共7页

基　　金：the Science and Technology Development Program of Shandong Province, No.032050116;the Natural Science Foundation of Shandong Province,No.ZR2010HM077;the 20 Staff Foundation of 1020 Project of Shandong Province 摘　　要：This study investigated the neuroprotective effect of Yiqi Bushen prescription (YQBS, supplementing qi and tonifying kidney) on neuronal cell apoptosis. Following YQBS treatment, the number of surviving hippocampal neurons increased, anti-apoptotic Bcl-2 expression increased and pro-apoptotic Bax expression decreased. In addition, diabetic rats exhibited improved learning and memory. YQBS treatment also increased Bcl-2 mRNA expression and the ratio of Bcl-2/Bax, but decreased levels of hypoxia-inducible factor-1α mRNA and Bax mRNA expression after high-glucose/hypoxia-induced injury. Results demonstrated that YQBS inhibited hippocampal neuronal apoptosis by decreasing hypoxia-inducible factor-1α expression and increasing Bcl-2 expression, thereby improving cognitive impairment in diabetic rats. 关键词：神经细胞凋亡糖尿病大鼠海马神经元补肾益气 BCL-2/BAX mRNA表达缺氧诱导因子

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Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats

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