Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

查看全文 作　　者：LUO [1]Nin;LU [2]Yingmei;JIANG [1,2]Yanbin

机构地区：[1]Star Lake Bioscience Co., Inc., Zhaoqing 526040, China;[2]School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 5 10640, China

出　　处：《Chinese Journal of Chemical Engineering》索引2011年第19卷第4期,共7页

基　　金：Supported by the National Natural Science Foundation of China (21076084 20676046); the Fundamental Research Funds for the Central Universities (2011ZZ0006) 摘　　要：Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature,pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases,the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng,Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters kij and lij can predict paclitaxel solubility for the best fit of experimental data. 关键词：超临界二氧化碳紫杉醇含量三元混合物二氯甲烷溶解度低临界溶液温度立方状态方程压力测定

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Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

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