Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

查看全文 作　　者：Lucia [1]Pacifico;Valerio [2]Nobili;Caterina [1]Anania;Paola [1]Verdecchia;Claudio [3]Chiesa

机构地区：[1]Department of Pediatrics,Sapienza University of Rome;[2]Department of Hepato-gastroenterology and Nutrition,Pediatric Hospital 'Bambino Gesù';[3]Institute of Translational Pharmacology,National Research Council

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第26期,共10页

摘　　要：Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol use.The mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic cirrhosis.NAFLD has become the most common cause of chronic liver disease in children and adolescents.The recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic worldwide.NAFLD is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin resistance.Thus,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of atherosclerosis.Accumulating evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk factors.Yet,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and MetS.Therefore,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular outcomes.In children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established effectively.Therapeutic goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD. 关键词：心血管疾病脂肪肝病代谢综合征酒精性肝疾病动脉粥样硬化小儿风险

相关文献

参考文献（105）
引证文献（24）
耦合文献（10）

参考文献(105)

引证文献(24)

耦合文献(10)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

参考文献(105)

引证文献(24)

耦合文献(10)

用户提示