Intestinal inflammation and colorectal cancer:A doubleedged sword?

查看全文 作　　者：Angelamaria [1]Rizzo;Francesco [1]Pallone;Giovanni [1]Monteleone;Massimo Claudio [1]Fantini

机构地区：[1]Department of Internal Medicine,University of Rome 'Tor Vergata'

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第26期,共9页

基　　金：Supported by'Associazione Italiana perla Ricerca sul Cancro',AIRC,MFAG-9353 and'Fondazione Umberto di Mario',Rome 摘　　要：Chronic inflammation is thought to be the leading cause of many human cancers including colorectal cancer(CRC).Accordingly,epidemiologic and clinical studies indicate that patients affected by ulcerative colitis and Crohn's disease,the two major forms of inflammatory bowel disease,have an increased risk of developing CRC.In recent years,the role of immune cells and their products have been shown to be pivotal in initiation and progression of colitis-associated CRC.On the other hand,activation of the immune system has been shown to cause dysplastic cell elimination and cancer suppression in other settings.Clinical and experimental data herein reviewed,while confirming chronic inflammation as a risk factor for colon carcinogenesis,do not completely rule out the possibility that under certain conditions the chronic activation of the mucosal immune system might protect from colonic dysplasia. 关键词：慢性炎症肠道疾病大肠癌溃疡性结肠炎粘膜免疫系统免疫细胞 CRC 流行病学

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Intestinal inflammation and colorectal cancer:A doubleedged sword?

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