IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients

查看全文 作　　者：Mauricio [1]Venegas;Rodrigo A [2]Villanueva;Katherine [1]González;Javier [1]Brahm

机构地区：[1]Centro de Estudios Avanzados de las Hepatitis Virales,Sección de Gastroenterología,Departamento de Medicina,Hospital Clínico Universidad de Chile;[2]Centro de Estudios Avanzados de las Hepatitis Virales,Laboratorio de Virus Hepatitis,Programa de Virología,Instituto de Ciencias Biomédicas,Facultad de Medicina,Universidad de Chile

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第31期,共4页

基　　金：Supported by The grant OAIC 394/10(to M.V.)from Hospital Clínico Universidad de Chile 摘　　要：AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV infection genotype 1,under standard combined treatment with pegylated interferon plus ribavirin.One group consisted of 50 patients with sustained virological response,whereas the second group consisted of 49 null responders.In order to analyze the IL28B single nucleotide polymorphisms rs12979860,rs12980275 and rs8099917,samples were used for polymerase chain reaction amplification,and the genotyping was performed by restriction fragment lengthpolymorphism.RESULTS:The IL28B rs12979860 CC,rs12980275 AA and rs8099917 TT genotypes were much more frequently found in patients with sustained virological response compared to null responders 38%,44% and 50% vs 2%,8.2% and 8.2%,respectively.These differences were highly significant in all three cases(P < 0.0001.CONCLUSION:The three IL28B polymorphisms studied are strongly associated with sustained virological response to therapy in Chilean patients with chronic CV genotype 1. 关键词：单核苷酸多态性聚合酶链反应丙型肝炎病毒联合治疗患者慢性智利限制性片段

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IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients

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