Effects of SO_(2)derivatives on sodium currents in acutely isolated rat hippocampal lead-exposed neurons

查看全文 作　　者：DU [1]ZhengQing;Lü [1]GuoPing

机构地区：[1]Department of Environmental Science,Shanxi University of Finance&Economics,Taiyuan 030006,China

出　　处：《Science China(Life Sciences)》索引2008年第51卷第9期,共6页

基　　金：the National Natural Science Foundation of China(Grant No.20637010);University of Science and Technology Foundation of Shanxi Prov-ince(Grant No.200713010) 摘　　要：In this study, the effects of acute SO_2 derivatives and chronic lead exposure together on sodium cur-rents (INa) were investigated in acutely isolated rat hippocampal neurons by using the whole-cell patch clamp techniques. We found that chronic lead exposure hardly reduced the amplitudes of INa. In the normal condition, sodium current started to appear at around ?70 mV, and reached the peak current at around ?40 mV. After chronic lead exposure, the data changed to ?70 and ?30 mV. After adding SO2 derivatives, the data changed to ?80 and ?40 mV, respectively. SO_2 derivatives caused a significant in-crease of INa in hippocampal chronic-lead exposed neurons. Chronic lead exposure induced a right shift of the activation curve and a left shift of the inactivation curve of sodium channels. SO_2 derivatives caused negative shifts of the activation and inactivation curves of INa in hippocampal chronic-lead ex-posed neurons. Lead exposure put off the time reaching the peak of INa activation. SO_2 derivatives in-creased the time constants of inactivation after lead exposure. The interaction of lead and SO_2 deriva-tives with voltage-dependent sodium channels may lead to changes in electrical activity and contribute to worsening the neurotoxicological damage. 关键词：SO_(2)derivatives LEAD hippocampal neurons whole-cell patch clamp techniques I_(Na)

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Effects of SO_(2)derivatives on sodium currents in acutely isolated rat hippocampal lead-exposed neurons

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