Experimental verifications on chemical carcinogenesis, a bifunctional alkvlation between DNA interstrands

查看全文 作　　者：DAI Qianhuan, ZHANG Qingrong, WANG Lihui, PEI Shu, WANG Qing &QUBoCenter for Chemistry and Bioengineering of Cancer, Beijing Polytechnic University, Beijing 100022, China

出　　处：《Chinese Science Bulletin》索引2000年第45卷第12期,共5页

摘　　要：It is evidenced by the filter elution method that two carcinogenic aromatic hydrocarbons, benzo[a]pyrene and dibenzo[a,h]anthracene, two carcinogenic metal salts, beryllium chloride and cadmium chloride, four carcinogenic aromatic amines, 2-aminofluorene, p-naphthylamine, 4-aminobiphenyl and benzidine, can all induce DNA interstrand and DNA-protein cross-link in L12io culture. However, under the same condition, the corresponding non-carcinogenic compounds, including benzo[k]fluorancene, anthracene, magnesium chloride, zinc chloride, a-naphthylamine, 2-aminobiphenyl and m-toluidine, cannot produce any cross-link adducts. All these results are consistent with the di-region theory that carcinogens are bio-bifunctional alkylation agents. This method can also be used to discriminate carcinogens and non-carcinogens. 关键词：mechanism of chemical carcinogenesis di-region theory DNA interstrand CROSS-LINK AROMATIC AMINES poiycyclic AROMATIC hydrocarbons BERYLLIUM SALT cadmium salt.

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Experimental verifications on chemical carcinogenesis, a bifunctional alkvlation between DNA interstrands

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