CELL AND MOLECULAR BIOMECHANICS: PERSPECTIVES AND CHALLENGES

查看全文 作　　者：Baohua [1]Ji;Gang [2]Bao

机构地区：[1]Department of Applied Mechanics, Beijing Institute of Technology, Beijing 100081, China;[2]Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA

出　　处：《Acta Mechanica Solida Sinica》索引2011年第24卷第1期,共25页

基　　金：supported by the National Heart,Lung,and Blood Institute,National Institutes of Health,as a Program of Excellence in Nanotechnology Award,N01 HV-08234,to Gang Bao;the support from the National Natural Science Foundation of China through Grant Nos.10872115,11025208 and 10732050 摘　　要：As an intriguing interdisciplinary research field,cell and molecular biomechanics is at the cutting edge of mechanics in general and biomechanics in particular.It has the potential to provide a quantitative understanding of how forces and deformation at tissue,cellular and molecular levels affect human health and disease.In this article,we review the recent advances in cell and molecular biomechanics,examine the available computational and experimental tools,and discuss important issues including protein deformation in mechanotransduction,cell deformation and constitutive behavior,cell adhesion and migration,and the associated models and theories.The opportunities and challenges in cell and molecular biomechanics are also discussed.We hope to provide readers a clear picture of the current status of this field,and to stimulate a broader interest in the applied mechanics community. 关键词：细胞黏附生物力学分子水平一般力学人类健康应用力学变形蛋白质

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CELL AND MOLECULAR BIOMECHANICS: PERSPECTIVES AND CHALLENGES

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