Oligomannuronate-Chromium (Ⅲ) Complex Ameliorates Insulin Resistance in C57BL/KsJ-db/db Mice

查看全文 作　　者：HAO [1,2]Cui;HAO [1,2]Jiejie;WANG [1,2]Wei;LI [1,2]Guangsheng;ZENG [1,2]Yangyang;WANG [1,2]Peipei;ZHAO [1,2]Xia;YU [1,2]Guangli

机构地区：[1]Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering;[2]Key Laboratory of Marine Drugs,Ministry of Education,Ocean University of China,Qingdao 266003,P.R.China

出　　处：《Journal of Ocean University of China》索引2011年第10卷第4期,共7页

基　　金：the Program for Changjiang Scholars and Innovative Research Team in University (IRT0944);the National Natural Science Foundation of China (31070724, 30870506);the Special Fund for Marine Scientific Research in the Public Interest (201005024);the International Science and Technology Collaboration Program of China (2007DFA30980);the Open Research Fund of Key Laboratory of Marine Drugs of the Ministry of Education;Ocean University of China (KLMD200802) 摘　　要：Diabetes mellitus is the most common metabolic disease and its prevalence is increasing in many countries year by year.More than 90% of diabetes patients are type 2 diabetes,which is caused by insulin resistance and beta-cell dysfunction.In this paper,the oligomannuronate-chromium(III)complex(OM2)was prepared and its effect and mechanism on attenuating insulin resistance in diabetic C57BL/KsJ-db/db mice were studied.The results indicated that oral intake of OM2(50 mg kg-1d-1)for 42 d decreased blood glucose and lipid concentration,which was associated with the reduced serum insulin concentration and insulin resistance.According to western blot assay,OM2 could activate AMPK pathway to regulate glycogen synthesis,gluconeogenesis and lipid metabolism in the liver,and attenuate the hyperglycemic symptom in db/db mice.The effects of OM2 on attenuating insulin resistance were com-parable to that of the established antidiabetic drug metformin,and OM2 showed less adverse effect than metformin in vivo.Based on the effectiveness and low toxicity,OM2 may potentially be used for prevention and treatment of type 2 diabetes mellitus. 关键词：db/db mice oligomannuronate-chromium(III)complex insulin resistance AMPK

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Oligomannuronate-Chromium (Ⅲ) Complex Ameliorates Insulin Resistance in C57BL/KsJ-db/db Mice

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