STRUCTURAL AND ADSORPTION RELATIONSHIP OF MACROPOROUS R ESIN IN HEMOPERFUSION

查看全文 作　　者：Baoan Li;Chunli Gao;Changzhi Chen;Yaoting Yu(Molecular Biology Institute,Bioactive MaterialsResearch Laboratory, Nankai University, Tianjin 300071,China) 出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》索引1998年第7卷第1期,共6页 摘　　要：In order to achieve high adsorption capacity of adsorbents in hemoperfusion,macroporous resins were tailor made with appropriate pore sizes and specific area. This allows the toxin molecules to diffuse freely within the channels ofthe porous resins and rinally reach the adsorption sites.Macroporous resin NK - 107 having small pore size and large Surface area(1086cm2) were synthesized which showed a high adsorption capacity of 82 - 94%for small molecules such as hypnotic and sedative drugs. For the adsorption of middle molecules i. e. Vit B12 or cytochrome C adsorbents having large pore sizes weretailor made. In the case of the adsorption of unconjugated bilirubin which is a verybig molecule, the pore size of the adsorbent should be at least>160A. NK - 110 istailor made with a very big pore size,which have a high adsorption capacity of 87%for bilirubin. DNA immobilized on carbonized resins,which have a porous structurewith a large surface area of 1000m2/g,can adsorb DNA antibody effectively. Resultsfrom animal and clinical trials indicated that the above tailor - made adsorbentshave a high efficacy in the removal of endogenous and exogenous toxins in hemoperfusion. 关 键 词：MACROPOROUS resin. HEMOPERFUSION adsorbents structure TOXINS