Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression

查看全文 作　　者：Yuanyuan Zhang Jianjun Jia Liping Chen Zhitao Han Yulan Zhao Honghong Zhang Yazhuo [1]Hu

机构地区：[1]Department of Neurology, South Building of Chinese PLA General Hospital, Beijing 100853, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第33期,共7页

基　　金：a grant from Science and Technology Bureau of Beijing, No.Z090507017709030 摘　　要：Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions. 关键词：大鼠模型单胺类神经递质抑郁症应激慢性中国传统医学去甲肾上腺素阳性神经元

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Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression

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耦合文献(60)

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