Characterization of the immune defense related tissues,cells,and genes in amphioxus

查看全文 作　　者：LIN [1]YuShuang;CHEN [1,2]DongYan;ZHANG [1]Wei;CAI [1]ZhaoPing;CHEN [1]ZhongKe;ZHANG [1]Ning;MAO [3]BingYu;ZHANG [1]HongWei

机构地区：[1]Life Science College, Shandong University, Key Laboratory of Experimental Teratology of Ministry of Education of China, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Jinan 250100, China;[2]Medical School, Nankai University, Tianjin 300071, China;[3]Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

出　　处：《Science China(Life Sciences)》索引2011年第54卷第11期,共6页

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434);Natural Science Foundation of Shandong Province (Grant No. Y2007D20);Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100) 摘　　要：Amphioxus is an important animal model for phylogenetic analysis,including comparative immunology.Exploring the immune system in amphioxus contributes to our understanding of the origin and evolution of the vertebrate immune system.We investigated the amphioxus immune system using ultrastructural examination and in situ hybridization.The expression patterns of TLR1(toll-like receptor 1),C1Q(complement component 1,q subcomponent),ECSIT(evolutionarily conserved signaling intermediate in Toll pathways),SoxC,DDAHa(Dimethylarginine dimethylaminohydrolase a),and NOS(nitric oxide synthase) show that these genes play key roles in amphioxus immunity.Our results suggest that the epidermis and alimentary canal epithelium may play important roles in immune defense,while macrophages located in the coelom and so-called lymph spaces may also be crucial immune cells. 关键词：免疫防御上皮细胞文昌鱼基因 Toll样受体组织特性系统发育分析

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Characterization of the immune defense related tissues,cells,and genes in amphioxus

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