Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

查看全文 作　　者：Ron [1]Benyair;Maria [1]Kondratyev;Elena [1]Veselkin;Sandra Tol-[1]chinsky;Marina [1]Shenkman;Yoav [2]Lurie;Gerardo Z [1]Lederkremer

机构地区：[1]Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University;[2]Liver Unit, Department of Gastroenterology, Tel Aviv Sourasky Medical Center

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第48期,共5页

基　　金：Supported by The Ramot research fund;the Israel Science Foundation;the Israel Cancer Association and the Israeli Ministry of Health (to Lederkremer GZ) 摘　　要：AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential. 关键词：Asialoglycoprotein 受体丙肝病毒肝功能肝硬化肝诊断

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Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

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