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Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population

查看全文 作　　者：Xiao-Ming [1]Zhou;Paul KS [2]Chan;John S [3]Tam 高影响力作者 机构地区：[1]Department of Epidemiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508,China;[2]Department of Microbiology, The Chinese University ofHong Kong, Shatin, Hong Kong, China;[3]World Health Organization, Geneva 1200, Switzerland高影响力机构 出　　处：《World Journal of Gastroenterology》索引2011年第17卷第48期,共7页高影响力期刊 基　　金：Supported by The National Key Technology Research and Development Program of China, No. 2009ZX10004-104 摘　　要：AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. METHODS: Thirty-seven HCV-1b samples were ob- tained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcomein this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported. CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong. 关 键 词：丙肝病毒 1b 扩大干扰素决定敏感的区域 干扰素 -- 抵抗 香港 变化
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