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Evaluating and Modeling the Mechanical Properties of the Prepared PLGA/nano-BCP Composite Scaffolds for Bone Tissue Engineering

查看全文 作　　者：M. Ebrahimian-[1,2]Hosseinabadi;F. [1]Ashrafizadeh;M. [3]Etemadifar;Subbu S. [4]Venkatraman 高影响力作者 机构地区：[1]Department of Materials Engineering, Isfahan University of Technology;[2]Isfahan University of Medical Sciences;[3]Orthopedic Departments, School of Medicine, Isfahan University of Medical Sciences;[4]Materials Science & Engineering School,Nanyang Technological University高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2011年第27卷第12期,共8页高影响力期刊 基　　金：supported by Isfahan University of Technology and Ministry of Sciences, Research & Technology in Iran and Materials Science & Engineering School of Nanyang Technological University in Singapore 摘　　要：In this paper, preparation of nano-biphasic calcium phosphate (nBCP), mechanical behavior and load-bearing of poly (lactide-co-glycolide) (PLGA) and PLGA/nBCP are presented. The nBCP with composition of 63/37 (w/w) HA/β-TCP (hydroxyapatite/β-tricalcium phosphate) was produced by heating of bovine bone at 700℃. Composite scaffolds were made by using PLGA matrix and 10-50 wt% nBCP powders as reinforcement material. All scaffolds were prepared by thermally induced solid-liquid phase separation (TIPS) at -60℃ under 4 Pa (0.04 mbar) vacuum. The results of elastic modulus testing were adjusted with Ishai-Cohen and Narkis models for rigid polymeric matrix and compared to each other. PLGA/nBCP scaffolds with 30 wt% nBCP showed the highest value of yield strength among the scaffolds. In addition, it was found that by increasing the nBCP in scaffolds to 50 wt%, the modulus of elasticity was highly enhanced. However, the optimum value of yield strength was obtained at 30 wt% nBCP, and the agglomeration of reinforcing particles at higher percentages caused a reduction in yield strength. It is clear that the elastic modulus of matrix has the significant role in elastic modulus of scaffolds, as also the size of the filler particles in the matrix. 关 键 词：SCAFFOLD Bone tissue engineering Poly (lactide-co-glycolide) (PLGA) Biphasic calcium phosphate Porous composite
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