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Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

查看全文 作　　者：Masaaki [1,2]Kodama;Kazunari [1]Murakami;Tadayoshi [1]Okimoto;Yoshihiro [3]Fukuda;Tadashi [4]Shimoyama;Masumi [3]Okuda;Chieko [5]Kato;Intetsu [6]Kobayashi;Toshio [1]Fujioka 高影响力作者 机构地区：[1]Department of Gastroenterology, Faculty of Medicine, Oita University;[2]Faculty of Medicine, Hasama Division, Health Science Center, Oita University;[3]General Medicine and Community Health Science, Hyogo College of Medicine;[4]Department of Gastroenterology, Hirosaki University, Graduate School of Medicine;[5]Toyama City Medical Association Health Management Center;[6]Department of Microbiology, Toho University高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第1期,共5页高影响力期刊 摘　　要：AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). 关 键 词：HELICOBACTER PYLORI STOOL antigen TEST Urea BREATH TEST Proton pump inhibitor
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