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Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease

查看全文 作　　者：Lars-Petter Jelsness-[1]Jφrgensen;Tomm [2]Bernklev;Magne [3]Henriksen;Roald [4]Torp;Bjφrn [5,6]Moum 高影响力作者 机构地区：[1]Department of Gastroenterology,Oslo University Hospital Aker and stfold Hospital Trust,1603 Fredrikstad,Norway;[2]Department of Research,Telemark Hospital Trust,3710 Skien,Norway;[3]Department of Gastroenterology,stfold Hospital Trust,1603 Fredrikstad,Norway;[4]Department of Gastroenterology,Innlandet Hospital Trust,2380 Brummundal,Norway;[5]Department of Gastroenterology,Oslo University Hospital;[6]Institute of Clinical Medicine,University of Oslo,0586 Oslo,Norway高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第5期,共8页高影响力期刊 基　　金：Supported by Oslo University Hospital Aker;stfold HospitalTrust;Ferring Pharmaceuticals 摘　　要：AIM:To investigate the impact of chronic fatigue on disease-related worries in inflammatory bowel disease (IBD) and the potential multicolinearity between subjective questionnaires.METHODS:Patients in remission or with mild-tomoderate disease activity completed the fatigue questionnaire (FQ),the rating form of IBD patient concerns (RFIPC),the Short-Form 36 (SF-36),and IBD questionnaire (N-IBDQ).In addition,clinical and epidemiological data were obtained.RESULTS:In total,140 patients were included;of which 92 were diagnosed with ulcerative colitis and 48 with Crohn's disease.The mean age of patients with chronic fatigue was 44.2 years (SD=15.8) and for non-fatigued patients was 44.7 years (SD=16.0).Chronic fatigued patients had clinically significantly increased levels of disease-related worries,as measured by Cohen's d effect size.Worries about having an ostomy bag,loss of bowel control,and energy levels were most prominent in both chronic fatigued and non-chronic fatigued IBD patients.Variance inflation factor (VIF) and tolerance indicated that there were no problematic multicolinearity among the FQ,RFIPC,SF-36 and N-IBDQ responses (VIF < 5 and tolerance > 2).CONCLUSION:Chronic fatigue is associated with increased levels of disease-related worries and concerns in IBD.Increased levels of worries were also associated with impaired health-related quality of life. 关 键 词：溃疡性结肠炎 临床疾病 疲劳 慢性 炎症 鸡传染性法氏囊病 IBD 平均年龄
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