Potential implications of Helicobacter pylori-related neutrophil-activating protein

查看全文 作　　者：Jannis [1]Kountouras;Christos [1]Zavos;Georgia [1]Deretzi;Emmanuel [1]Gavalas;Dimitrios [1]Chatzopoulos;Panagiotis [1]Katsinelos;Elena [1]Tsiaousi;Stergios [1]Gagalis;Stergios A [1]Polyzos;Ioannis [1]Venizelos

机构地区：[1]Department of Medicine,Second Medical Clinic,Aristotle University of Thessaloniki,Ippokration Hospital,Thessaloniki,Greece

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第5期,共2页

摘　　要：Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. 关键词：中性粒细胞激活蛋白幽门螺旋杆菌水通道蛋白4 幽门螺杆菌细胞毒素序列同源性特异性抗体

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Potential implications of Helicobacter pylori-related neutrophil-activating protein

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