A rare case of langerhans cell histiocytosis of the gastrointestinal tract

查看全文 作　　者：Uday [1]Shankar;Monika [1]Prasad;Om P [2]Chaurasia

机构地区：[1]Internal Medicine,Mount Sinai School of Medicine at Queens Hospital Center,Jamaica,NY 11432,United States;[2]Department of Medicine,University of California,Irvine,CA 92697,United States

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第12期,共4页

摘　　要：Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized,bone marrow-derived langerhans cells and mature eosinophils.The clinical spectrum ranges from an acute,fulminant,disseminated disease called LettererSiwe disease to solitary or few,indolent and chronic lesions of the bone or other organs called eosinophilic granuloma.Involvement of the gastrointestinal tract is very rare in LCH.We present the case of a 53-yearold woman referred by her primary care physician for a screening colonoscopy.A single sessile polyp,measuring 4 mm in size,was found in the rectum.Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm.The nuclei within these cells had frequent grooves and were occasionally folded.Immunohistochemical staining was positive for CD1a which confirmed the diagnosis of LCH.On further workup,there was no evidence of involvement of any other organ.On follow up colonoscopy one year later,there was no evidence of disease recurrence.Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare.However,with the increas-ing rates of screening colonoscopy,more colonic polyps may be identified as LCH on histopathology.This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease. 关键词：细胞增生细胞组织胃肠道全身性疾病嗜酸性粒细胞病理检查免疫组化染色 LCH

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A rare case of langerhans cell histiocytosis of the gastrointestinal tract

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