Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

查看全文 作　　者：Jian [1,2]LIU;Jian-zhong [1,2]SHENTU;Li-hua [1,2]WU;Jing [1]DOU;Qi-yang [1]XU;Hui-li [1,2]ZHOU;Guo-lan [1,2]WU;Ming-zhu [1,2]HUANG;Xing-jiang [1,2]HU;Jun-chun [1,2]CHEN

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Infectious Disease Center,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;[2]Research Center for Clinical Pharmacy,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》索引2012年第13卷第5期,共8页

基　　金：Project supported by the 12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China(No. 2011ZX09302-003-03);the Zhejiang Provincial Medicine and Health Research Fund(No.2008A064);the Jiangsu Hengrui Medicine Co.,Ltd.,China 摘　　要：In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total of 32 volunteers participated in the study. Plasma concentrations were analyzed by non- stereospecific liquid chromatography/tandem mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative bioavailability was assessed by calculating individual AUC0-t (the area under the concentration-time curve from time zero to the last measurable concentration), AUC0-∞ (the area under the concentration-time curve extrapolated to infinity), Cmax (the maximum observed concentration), and Tpeak (the time to Cmax) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals (CIs) of AUC0-t, AUC0-∞, and Cmax were 85.4%-99.0%/88.8%-98.6%/87.6%-99.4%, 85.5%-99.2%/89.0%-98.6%/88.5%-101.3%, and 72.3%-87.6%/79.6%-91.1%/88.4%-99.1% for OPZ/OH-OPZ/ OPZ-SFN, respectively, and Tpeak values did not differ significantly. In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, Cmax, and Tpeak. 关键词：生物利用度药代动力学奥美拉唑制剂 LC-MS/MS 血浆浓度时间曲线肠

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Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

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