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Does repair of spinal cord injury follow the evolutionary theory?

查看全文 作  者:Zhicheng [1]Zhang;Fang [1]Li;Tiansheng [1]Sun 高影响力作者 机构地区:[1]PLA Institute of Orthopedics,Beijing Army General Hospital,Beijing 100700,China高影响力机构 出  处:《Neural Regeneration Research》索引2012年第7卷第11期,共4页高影响力期刊 基  金:supported by the National Natural Science Foundation of China,No. 30872604 摘  要:Lower vertebrates,such as fish and amphibians,and higher vertebrates in embryonic development can acquire complete regeneration of complex body structures,including the spinal cord,an important part of the central nervous system.However,with species evolution and development,this regenerative capacity gradually weakens and even disappears,but the cellular and molecular mechanisms remain poorly understood.We explored the differences in mechanisms of spinal cord regeneration capability between lower and higher vertebrates,investigated differences in their cellular and molecular mechanisms and between the spinal cord structures of lower vertebrates and mammals,such as rat and monkey,to search for theoretical evidence and therapeutic targets for nerve regeneration in human spinal cord. 关 键 词:脊髓损伤 进化理论 脊椎动物 修复 中枢神经系统 再生能力 分子机制 身体结构
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