Family history influences the early onset of hepatocellular carcinoma

查看全文 作　　者：Chung-Hwa [1]Park;Seung-Hee [2,3]Jeong;Hyeon-Woo [2,3]Yim;Jin Dong [1]Kim;Si Hyun [1]Bae;Jong Young [1]Choi;Seung Kew [1]Yoon

机构地区：[1]Department of Internal Medicine, The Catholic University of Korea,Seoul 137-701, South Korea;[2]Department of Preventive Medicine, College of Medicine, The Catholic University of Korea,Seoul 137-701, South Korea;[3]Clinical Research Coordinating Center of Catholic Medical Center, The Catholic University of Korea,Seoul 137-701, South Korea

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第21期,共7页

基　　金：Supported by Nuclear R and D Program of the Ministry of Science and Technology, South Korea, No. 2010-0017595;a grant from the Korea Health 21 R and D Project, No. A070001,Ministry of Health and Welfare, South Korea 摘　　要：AIM: To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients. METHODS: We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 (92.6%) did not. The male to female ratio was 3.6:1, and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years (range: 29-79 years) and 57 years (range: 18-89 years), respectively (P < 0.0001). Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%), whereas those out of 1577 patients with negative family history was 197 (12.5%), suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P = 0.0028). CONCLUSION: More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present. 关键词：原发性肝癌早期诊断家族史病毒感染发病乙型肝炎病毒肝细胞癌丙型肝炎

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Family history influences the early onset of hepatocellular carcinoma

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