Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

查看全文 作　　者：Yao-Jong [1]Yang;Bor-Shyang [2]Sheu;Hsiao-Bai [3,4]Yang;Cheng-Chan [4]Lu;Ching-Chun [5]Chuang

机构地区：[1]Departments of Pediatrics and Institute ofClinical Medicine, Medical College, National Cheng Kung Uni-versity, Tainan 70428, Taiwan, China;[2]Departments of Internal Medicine and In-stitute of Clinical Medicine, Medical College, National ChengKung University, Tainan 70428, Taiwan, China;[3]Ton-Yen General Hospital, Hsinchu County70428 Taiwan, China;[4]Department of Pathology,Medical College, National Cheng Kung University, Tainan70428, Taiwan, China;[5]Institute of Clinical Medicine, MedicalCollege, National Cheng Kung University, Tainan 70428, Tai-wan, China

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第21期,共8页

基　　金：Supported by National Cheng Kung University Hospital, Tainan,China, No. NCKUH96-030;DOH99-TD-C-111-003 from Department of Health,Taiwan, China, No. DOH99-TD-C-111-003 摘　　要：AIM: To determine whether Helicobacter pylori (H. pylori)infected children have reduced body weight (BW) and height (BH) growth, and if H. pylori eradication may restore growth while improving serum acylated ghrelin. METHODS: This longitudinal cohort study with oneyear follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H. pylori ) and intervention cohort (75 with and 811 without). The 7-d triple therapy was used for eradication in the intervention cohort. The net increases of BW and BH as well serum acylated ghrelin after oneyear follow-up were compared between successful eradicated H. pylori-infected children and controls. RESULTS: In the observation cohort, the H. pylori - infected children had lower z score of BW (-1.11 ± 0.47 vs 0.35 ± 0.69, P = 0.01) and body mass index (BMI) (0.06 ± 0.45 vs 0.44 ± 0.73, P = 0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ± 2.1 kg vs 4.5 ± 2.4 kg, P = 0.04) than the non-infected controls. In the intervention cohort, the H. pylori - infected children had lower z score of BMI (0.25 ± 1.09 vs 0.68 ± 0.87, P = 0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL, P < 0.001) than the non-infected controls. In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0 pg/mL vs 44.2 ± 39.0 pg/mL, P < 0.001), the H. pylori - infected children with successful eradication had higher net gains (P < 0.05) and increase of z scores (P < 0.05) of both BW and BH as compared with non-infected controls after one-year follow-up. CONCLUSION:H. pylori-infected children are associated with low serum acylated ghrelin and growth retardation. Successful eradication of H. pylori restores ghrelin levels and increases growth in children. 关键词：GHRELIN 幽门螺杆菌儿童血清根除酰化生长幽门螺旋杆菌

相关文献

参考文献（33）
引证文献（13）
耦合文献（9）

参考文献(33)

引证文献(13)

耦合文献(9)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

参考文献(33)

引证文献(13)

耦合文献(9)

用户提示