维普中文期刊产品整合服务

Simultaneous estimation of genetic linkage and preferential pairing factor for a triploid population with unphased markers

查看全文 作　　者：WANG [1,2]JianXin;DONG [1]XiaoLi;PANG [2,3,4]XiaoMing;LV [2]YaFei;YI [5]HuaLin;YANG [2]XiaoXia;WANG [2,6]Zhong;WU [7]Song;WU [2,3,4,6]RongLing 高影响力作者 机构地区：[1]School of Information, Beijing Forestry University, Beijing 100083, China;[2]Center for Computational Biology, Beijing Forestry University, Beijing 100083, China;[3]National Engineering Laboratory for Tree Breeding, Beijing Forestry University, Beijing 100083, China;[4]Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Beijing Forestry University, Beijing 100083, China;[5]The National Key Laboratory for Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China;[6]Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA;[7]Department of Applied Mathematics & Statistics, State University of New York, Stony Brook, NY 11794, USA高影响力机构 出　　处：《Chinese Science Bulletin》索引2012年第57卷第21期,共10页高影响力期刊 基　　金：supported by Fundamental Research Funds for the Central Universities(YX2011-30,YX2010-30,BLYX200924and JD2010-5);Special Fund for Forestry-Scientific Research in the Public Interest(201004017);National Natural Science Foundation of China(61170268);China Agricultural Research System-CARS;NSF/IOS-0923975;Changjiang Scholars Award;'Thousand-person Plan'Award 摘　　要：Triploids,recognized to occur more frequently in natural and experimental populations of many species than previously appreciated,display important economic and biological values.Despite this,however,linkage analysis for triploids has not been well explored.We develop a statistical model for estimating and testing the linkage between molecular markers in a triploid population derived from a tetraploid and diploid parent.The model incorporates one important meiotic feature of tetraploids by which more homologous chromosomes pair with a greater likelihood than less homologous chromosomes.By implementing the EM algorithm within the maximum likelihood framework,the model provides a procedure for simultaneous estimation of the linkage and preferential pairing factor.The model accommodates the segregating patterns of pseudotest markers and intercross markers with different amounts of informativeness.The utility of the model was validated through a real data analysis and simulation studies.The model provides a statistical tool for linkage analysis in a triploid population by taking into account meiotic behavior of tetraploids.Results from the model will help to shed light on the genetic diversity and origin of a polyploid population. 关 键 词：分子标记 同时估计 三倍体 人口 遗传连锁 配对 减数分裂行为 模型估算
相关文献

参考文献(29)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费