Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic

查看全文 作　　者：LI [1,2]HaiXia;LIU [1,2]YanCheng;TANG [1,2]RuiZhi;ZHANG [1,2]Peng;FU [1]HaiYing;YAO [1]SiDe;WANG [1]WenFeng

机构地区：[1]Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China;[2]Graduate University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Chemistry》索引2012年第55卷第7期,共6页

基　　金：supported by the National Natural Science Foundation of China (21173252) 摘　　要：The reactions between gatifloxacin(GFX) and various one-electron oxidants,such as ˙OH,N3˙,Br2˙ˉ,and SO4˙ˉ,have been studied by pulse radiolysis techniques.The GFX radical anion formed in the reaction of GFX with eaqˉ could either be protonated or deprotonated,and the absorption of GFX radical anion was located at 390 nm.The transient species produced by the reaction of GFX with ˙OH radical shows a broad band in the 380?600 nm region with a shoulder,while the oxidation by N3˙,SO4˙ˉ,and Br2˙ˉ results in an absorption band with λmax = 370 nm.At neutral condition(pH 7),the rate constants of GFX reacting with ˙OH,N3˙,Br2˙ˉ,SO4˙ˉ and eaqˉ are estimated to be 1.0 × 1010,3.1 × 109,2.8 × 109,3.0 × 109,and 1.8 × 1010 dm3 mol?1 s?1,respectively.From the pH dependence on the formation of electron adducts and on the rate constant of GFX with eaqˉ,the pKa of GFX radical anion is estimated to be 5.5 and 9.3. 关键词：脉冲辐解技术加替沙星氟喹诺酮抗生素阴离子自由基质子化反应反应速率常数 GFX

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Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic

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