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Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity

查看全文 作　　者：Xiaohui [1]Wen;Ningyu [1]Wang;Jinfeng [1]Liu;Zhanfeng [1]Yan;Zhonghai [2]Xin 高影响力作者 机构地区：[1]Department of Otolaryngology Head & Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;[2]Department of Otolaryngology, Beijing Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China高影响力机构 出　　处：《Neural Regeneration Research》索引2012年第7卷第20期,共8页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China,No. 30973309 摘　　要：In this experiment,97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups(mild,moderate,severe) according to minimum oxygen saturation,and 35 healthy subjects were examined as controls.Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment.The results revealed that as the disease worsened,the mismatch negativity latency was gradually extended,and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome.Importantly,mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation < 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation > 60 seconds.Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores.These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores.As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients,the sensitivity of mismatch negativity is 82.93%,the specificity is 73.33%,the accuracy rate is 81.52%,the positive predictive value is 85.00%,the negative predictive value is 70.21%,the positive likelihood ratio is 3,and the negative likelihood ratio is 0.23.These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients. 关 键 词：睡眠呼吸暂停 认知功能障碍 不匹配 综合征 患者 通气 阻塞 检测
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