O-linked N-acetylglucosamine transferase(OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma

查看全文 作　　者：Zhe [1]Qiao;Chengxue [2]Dang;Bin [1]Zhou;Shaomin [1]Li;Wei [1]Zhang;Jiantao [1]Jiang;Jin [1]Zhang;Ranran [1]Kong;Yuefeng [1]Ma

机构地区：[1]Department of Thoracic Surgery,the Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China;[2]Department of Surgical Oncology,the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China

出　　处：《The Journal of Biomedical Research》索引2012年第26卷第4期,共6页

摘　　要：The aim of this present study was to explore the expression and clinical significance of O-linked N-acetylglucosamine(O-GlcNAc) transferase(OGT) and enzymatic O-linked glycosylation(O-GlcNAcation) through the addition of O-linked-β-N-acetylglucosamine in esophageal squamous cell carcinoma.OGT expression and O-GlcNAcation in 40 samples from patients with esophageal squamous cell carcinoma was detected by immunohistochemical staining with anti-OGT antib ody and O-GlcNAc-specific antibody RL 2,respectively.The relationship between pathological and clinical factors of patients was analyzed.We found that the expression of OGT was higher in esophageal squamous cell carcinoma samples compared to the normal tissues.RL 2 antibody level was positively correlated with OGT expression,and the metastasis of lymph node,which means the level of O-GlcNAcation was high and related to the metastasis of lymph node in esophageal squamous cell carcinoma.In conclusion,OGT activation is the main reason for promoting the level of O-GlcNAcation in esophageal squamous cell carcinoma.O-GlcNAcylation may play an important role in esophageal squamous cell carcinoma. 关键词：乙酰氨基葡萄糖鳞状细胞癌转移酶糖基化食管过度表达免疫组织化学染色蛋白

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O-linked N-acetylglucosamine transferase(OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma

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