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Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

查看全文 作  者:Jian [1]Huo;Jiachuan [1]Liu;Jinbiao [1]Wang;Yongming [1]Zhang;Chunlin [1]Wang;Yanyan [1]Yang;[1]WenjiangSun;Shaonian [1]Xu 高影响力作者 机构地区:[1]Department of Neurosurgery,the 105 Hospital of Chinese PLA,Hefei 230032,Anhui Province,China高影响力机构 出  处:《Neural Regeneration Research》索引2012年第7卷第22期,共7页高影响力期刊 基  金:supported by the Eleventh-Five Major Subjects of Nanjing Military Area Command,No.06Z19;the Military Medical Science and Technology Innovation Foundation in 2009,No.09Z009 摘  要:In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast-induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression. 关 键 词:促肾上腺皮质激素 水通道蛋白4 高压氧治疗 颅脑损伤 脑下垂体 早期 爆炸
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