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Mitochondrial DNA mutations-candidate biomarkers for breast cancer diagnosis in Bangladesh

查看全文 作　　者：Gazi Nurun Nahar [1]Sultana;Atiqur [2]Rahman;Abu Din Ahmed [3]Shahinuzzaman;Rowshan Ara [4]Begum;Chowdhury Faiz [5]Hossain 高影响力作者 机构地区：[1]Centre for Advanced Research in Sciences,University of Dhaka,Dhaka 1000,Bangladesh;[2]Department of Microbiology,University of Dhaka,Dhaka 1000,Bangladesh;[3]Department of Genetic Engineering and Biotechnology,University of Dhaka,Dhaka 1000,Bangladesh;[4]National Cancer Research Institute and Hospital,Mohakhali,Dhaka 1212,Bangladesh;[5]East West University,Mohakhali,Dhaka 1212,Banglades高影响力机构 出　　处：《Chinese Journal of Cancer》索引2012年第31卷第9期,共6页高影响力期刊 基　　金：supported by grants from the Centre for Advanced Research in Sciences(CARS),University of Dhaka 摘　　要：Breast cancer is a major health problem that affects more than 24% of women in Bangladesh. Furthermore, among low-income countries including Bangladesh, individuals have a high risk for developing breast cancer. This study aimed to identify candidate mitochondrial DNA (mtDNA) biomarkers for breast cancer diagnosis in Bangladeshi women to be used as a preventive approach. We screened the blood samples from 24 breast cancer patients and 20 healthy controls to detect polymorphisms in the D-loop and the ND3-and ND4-coding regions of mtDNA by direct sequencing. Among 14 distinct mutations, 10 polymorphisms were found in the D-loop, 3 were found in the ND3-coding region, and 1 was found in the ND4-coding region. The frequency of two novel polymorphisms in the D-loop, one at position 16290 (Tins) and the other at position 16293 (A-del), was higher in breast cancer patients than in control subjects (position 16290: odds ratio = 6.011, 95% confidence interval = 1.2482 to 28.8411, P = 0.002; position 16293: odds ratio = 5.6028, 95% confidence interval = 1.4357 to 21.8925, P = 0.010). We also observed one novel mutation in the ND3-coding region at position 10316 (A > G) in 69% of breast cancer patients but not in control subjects. The study suggests that two novel polymorphisms in the D-loop may be candidate biomarkers for breast 关 键 词：线粒体DNA突变 生物标志物 孟加拉国 乳腺癌 诊断 基因编码区 基因多态性 D-LOOP区
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