Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

查看全文 作　　者：Neven Bari[1];Ivan Leroti[1];Lea Smiri-[2]Duvnjak;Vedran Tomai[1];Marko [1]Duvnjak

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Medicine,'Sestre milosrdnice' University Hospital Center,10000 Zagreb,Croatia;[2]Vuk Vrhovac University Clinic for Diabetes,Endocrinology and Metabolic Diseases,10000 Zagreb,Croatia

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第30期,共10页

摘　　要：High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. 关键词：脂肪肝病诊断工具肝疾病酒精性生物标志物肝纤维化磁共振成像侵入性

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Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

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