Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function

查看全文 作　　者：Fang Fang Zhanggang Xue Jing [1]Cang

机构地区：[1]Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

出　　处：《Neuroscience Bulletin》索引2012年第28卷第5期,共10页

基　　金：supported by the Science and Technology Commission of Shanghai Municipality, China (09jc1403500) 摘　　要：Objective Sevoflurane is widely used in pediatric anesthesia and former studies showed that it causes neurodegeneration in the developing brain. The present study was carried out to investigate the effects of sevoflurane on neurogenesis, neurodegeneration and behavior. Methods We administered 5-bromodeoxyuridine, an S-phase marker, before, during, and after 4 h of sevoflurane given to rats on postnatal day 7 to assess dentate gyrus progenitor proliferation and Fluoro-Jade staining for degeneration. Spatial reference memory was tested 2 and 6 weeks after anesthesia. Results Sevoflurane decreased progenitor proliferation and increased cell death until at least 4 days after anesthesia. Spatial reference memory was not affected at 2 weeks but was affected at 6 weeks after sevoflurane administration. Conclusion Sevoflurane reduces neurogenesis and increases the death of progenitor cells in developing brain. This might mediate the lateonset neurocognitive outcome after sevoflurane application. 关键词：神经退行性疾病七氟醚认知功能大鼠日龄细胞增殖细胞死亡细胞发育

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Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function

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