Colorectal cancer in patients with inflammatory bowel disease:Can we predict risk?

查看全文 作　　者：Vibeke [1,2]Andersen;Jonas [3]Halfvarson;Ulla [4]Vogel

机构地区：[1]Medical Department,Sygehus Sφnderjylland Aabenraa,DK-6200 Aabenraa,Denmark;[2]Institute of Regional Health Services Research,University of Southern Denmark,DK-5000 Odense,Denmark;[3]Department of Internal Medicine,rebro University Hospital,rebro University,rebro 70185,Sweden;[4]National Research Centre for the Working Environment,DK-2100 Copenhagen,Denmark

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第31期,共4页

摘　　要：The inflammatory bowel diseases(IBD),Crohn's disease(CD) and ulcerative colitis(UC),may be complicated by colorectal cancer(CRC).In a recent populationbased cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation.The overall risk of CRC among patients with UC and CD was comparable with that of the general population.However,patients diagnosed with UC during childhood or as adolescents,patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk.In this commentary,we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients.Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC.The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD.The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients.The achieved knowledge may also be relevant for other inflammation-associated cancers. 关键词：风险预测肠道疾病预测模型大肠癌患者鸡传染性法氏囊病溃疡性结肠炎临床实践

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Colorectal cancer in patients with inflammatory bowel disease:Can we predict risk?

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