Biogenesis of Mammalian MicroRNAs:A Global View

查看全文 作　　者：Paul [1]Graves;Yan [2]Zeng

机构地区：[1]Department of Radiation Oncology, New York Methodist Hospital, Weill Cornell Medical College, Brooklyn, NY 11215, USA;[2]Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA

出　　处：《Genomics, Proteomics & Bioinformatics》索引2012年第10卷第5期,共7页

基　　金：the support of the American Heart Association(Grant No. 0835471N) 摘　　要：MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA production is controlled in vivo. 关键词：小分子RNA 哺乳动物 MIRNAS 视野非编码RNA 基因表达真核生物核苷酸

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Biogenesis of Mammalian MicroRNAs:A Global View

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